LEO WAITZKIN, M.D.
The complete pathogenesis of jaundice due to chlorpromazine is obscure, but a number of facts have become known.
Approximately 1% of people treated with chlorpromazine for two or more weeks have developed clinical jaundice.1 Its appearance has first been noted 10 to 31 days after the initiation of drug therapy,2, 3, 4 and as long as 18 days after withdrawal of the drug.2, 5, 6 Its incidence and severity have not been influenced by age, sex, size of daily dose or duration of drug therapy before icterus. It has occurred after as little as 50 to 75 mg. taken for
WAITZKIN L. HEPATIC DYSFUNCTION DUE TO CHLORPROMAZINE HYPERSENSITIVITY1. Ann Intern Med. ;49:607–619. doi: 10.7326/0003-4819-49-3-607
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Published: Ann Intern Med. 1958;49(3):607-619.
Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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