E. BRAUN-MENÉDEZ, M.D., F.A.C.P. (Hon.)
The role of the kidney in experimental renal hypertension—and probably also in human renal hypertension—is twofold. On the one hand, it has a prohypertensive action mediated by the release into the blood of a pressor substance, renin, which, by acting on a serum α-globulin, produces "angiotensin," an octapeptide with potent vasoconstrictor and pressor actions.
On the other hand, the normal kidney tissue exerts some kind of antihypertensive action the exact nature of which is still unknown.
This dual and contrariwise role is not unique in the organism. For instance, the adrenal cortex secretes hormones which may have opposite actions on
BRAUN-MENÉDEZ E. THE PROHYPERTENSIVE AND ANTIHYPERTENSIVE ACTIONS OF THE KIDNEY1. Ann Intern Med. ;49:717–731. doi: 10.7326/0003-4819-49-4-717
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Published: Ann Intern Med. 1958;49(4):717-731.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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