GEORGE J. FRIOU, M.D.
The description of the L.E. phenomenon by Hargraves is recognized as an important milestone in the advance of our knowledge of the rheumatic diseases.1 This observation has aroused a great increase in interest in disseminated lupus erythematosus. In particular, the L.E. phenomenon has attracted the attention of investigators because of the feeling that knowl-edge of its mechanisms would reveal other important clues regarding the disease. Presented here is a review of some recent investigations related to this problem.
Particularly pertinent to our discussion is the work of Haserick,2 who demonstrated that the L.E. factor
FRIOU GJ. THE SIGNIFICANCE OF THE LUPUS GLOBULIN-NUCLEOPROTEIN REACTION12. Ann Intern Med. ;49:866–875. doi: 10.7326/0003-4819-49-4-866
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Published: Ann Intern Med. 1958;49(4):866-875.
Lupus Erythematosus, Rheumatology.
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