ROBERT L. BIBEN, M.D.; MARVIN L. TYAN, M.D.
Acute hemorrhagic syndromes may occasionally develop in association with carcinoma of the stomach,1-4 prostate,5 pancreas4 or gall-bladder.2 Tagnon6 has demonstrated the presence of a proteolytic enzyme in both normal and malignant prostatic tissue which produces fibrinolysis and bleeding in patients with metastatic carcinoma of the prostate. Recently, Frick4 reported four cases of carcinoma—two of the stomach, one of the pancreas and one of the prostate—in which hemorrhagic tendencies involved deficiencies of fibrinogen, prothrombin, labile prothrombin conversion factor, and antihemophilic globulin. It is the purpose of this paper to report a case of carcinoma of the stomach complicated by deficiencies of
BIBEN RL, TYAN ML. HEMORRHAGIC DIATHESIS IN CARCINOMA OF THE STOMACH: A CASE REPORT1. Ann Intern Med. ;49:917–922. doi: 10.7326/0003-4819-49-4-917
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Published: Ann Intern Med. 1958;49(4):917-922.
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