JOSEPH W. FERREBEE, M.D.; E. DONNALL THOMAS, M.D., F.A.C.P.
Exposure of the entire body to ionizing radiation 2 in the range of 500 to 1,000 Roentgens (r) is followed by death in from seven to 14 days.1 A failure of marrow function is the primary cause of this death, and the symptoms are primarily those of bleeding and septicemia. In a number of animal species—mice,2 rats, rabbits,3 dogs,4 monkeys,5 and chimpanzees6—death of this type can be avoided by the intravenous infusion of homologous marrow cells 3 a day or two after the exposure to radiation. The infused marrow cells "home" to their appropriate sites in the marrow of
FERREBEE JW, THOMAS ED. RADIATION INJURY AND MARROW REPLACEMENT: FACTORS AFFECTING SURVIVAL OF THE HOST AND THE HOMOGRAFT1. Ann Intern Med. 1958;49:987–1003. doi: 10.7326/0003-4819-49-5-987
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Published: Ann Intern Med. 1958;49(5):987-1003.
Hospital Medicine, Infectious Disease, Multi-Organ Failure and Sepsis, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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