JOHN C. BECK, M.D.; E. E. MCGARRY, M.D.; I. DYRENFURTH, Ph.D.; E. H. VENNING, Ph.D.
The biochemical nature and diverse physiologic effects of pituitary growth hormone have been reviewed recently by a number of investigators in an international symposium,1 by Astwood,2 Randle,3 Ketterer et al.,4 Li5 and Hays and Steelman.6 A recent development has been the observations which suggest a degree of specificity among growth hormones obtained from different species. Normal and hypophysectomized guinea pigs fail to respond to bovine growth hormone,7 fish growth hormone is inactive in the rat,8 while fish and bovine growth hormones are active in intact and hypophysectomized fish.9-12 Knobil13-17 demonstrated that both intact and hypophysectomized monkeys fail to respond
BECK JC, MCGARRY EE, DYRENFURTH I, VENNING EH. THE METABOLIC EFFECTS OF HUMAN AND MONKEY GROWTH HORMONE IN MAN12. Ann Intern Med. ;49:1090–1105. doi: 10.7326/0003-4819-49-5-1090
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Published: Ann Intern Med. 1958;49(5):1090-1105.
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