PAUL N. YU, M.D., F.A.C.P.
With few exceptions, the diagnosis of primary pulmonary hypertension was made only at necropsy prior to the introduction of cardiac catheterization. Pathologists referred to this condition as primary pulmonary arteriosclerosis,1 right ventricular hypertrophy of unknown origin,2 primary pulmonary vascular sclerosis,3, 4 and obliterative pulmonary arteriosclerosis.5 The disease was thought to be rare. In 1931 McCallum5 reported only one instance of obliterative pulmonary arteriosclerosis in 12,000 autopsies. In 1954 Goodale and Thomas,6 in 10,000 autopsies, found two cases which fulfilled their criteria for the diagnosis of primary pulmonary arteriosclerosis.
Clinical and pathologic studies of this disease with extensive reviews of the
YU PN. PRIMARY PULMONARY HYPERTENSION: REPORT OF SIX CASES AND REVIEW OF LITERATURE12. Ann Intern Med. ;49:1138–1161. doi: 10.7326/0003-4819-49-5-1138
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Published: Ann Intern Med. 1958;49(5):1138-1161.
Pulmonary Hypertension, Pulmonary/Critical Care.
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