JOHN M. WELLER, M.D., F.A.C.P.; SIBLEY W. HOOBLER, M.D., F.A.C.P.
It is an established fact that sodium chloride metabolism is abnormal in essential hypertension. However, the exact role which the disordered salt metabolism plays in either the pathogenesis or the perpetuation of this disease is not clear. Both the distribution of sodium within the body and its elimination by the kidney are altered. It has been demonstrated that patients with essential hypertension have slightly elevated serum sodium concentrations.1, 2 In some subjects there is an expansion of the total body sodium, and it has been postulated that this excess sodium is located intracellularly.3 The arterial wall of both hypertensive patients
WELLER JM, HOOBLER SW. SALT METABOLISM IN HYPERTENSION(SALT METABOLISM IN HYPERTENSION*†)(SALT METABOLISM IN HYPERTENSION*†). Ann Intern Med. 1959;50:106–114. doi: 10.7326/0003-4819-50-1-106
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Published: Ann Intern Med. 1959;50(1):106-114.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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