PAUL W. CLOUGH, M.D.
The relationship between renal ischemia and hypertension was first clearly demonstrated and brought to general notice by Goldblatt (1934). By applying a clamp to the renal artery so as partially to obstruct the circulation to the kidney, he was able to produce sustained hypertension in some dogs (and also monkeys) which had some clinical resemblance to essential hypertension in man. Release of the clamp or timely removal of the ischemic kidney usually resulted in prompt subsidence of the hypertension if the other kidney was normal. Something instrumental in increasing blood pressure is evidently elaborated or produced in increased quantity by
CLOUGH PW. UNILATERAL RENAL ISCHEMIA AS A CAUSE OF HYPERTENSION. Ann Intern Med. ;50:232–238. doi: 10.7326/0003-4819-50-1-232
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Published: Ann Intern Med. 1959;50(1):232-238.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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