RUSSELL E. RANDALL JR.; ELSIE C. ROSSMEISL; KENNETH H. BLEIFER
The discovery of a neuromuscular disorder in animals specifically related to a deficiency of magnesium1-9 has led to investigation of this ion in various clinical disorders in man.10-31 Studies have been seriously handicapped by several factors. The quantitative determination of magnesium has proved troublesome, particularly with the older precipitation methods.32-34 The current methods employing colorimetric technics,35-37 and the newer methods employing flame photometry,38 spectrography39-41 and versene chelation,42-44 are rapidly overcoming this barrier. The natural distribution of the magnesium ion has been a particularly troublesome problem. Its location chiefly within cells and bone makes difficult the interpretation of many studies concerned
RANDALL RE, ROSSMEISL EC, BLEIFER KH. MAGNESIUM DEPLETION IN MAN1. Ann Intern Med. 1959;50:257–287. doi: 10.7326/0003-4819-50-2-257
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Published: Ann Intern Med. 1959;50(2):257-287.
Hospital Medicine, Nephrology.
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