WILLIAM J. HAMMACK, M.D.; F. ELNA BOLDING, B.S.; WALTER B. FROMMEYER JR., M.D., F.A.C.P.
Plasma protein electrophoretic patterns revealing discrete and homogeneous globulin peaks have been interpreted to indicate either multiple myeloma, cryoglobulinemia or macroglobulinemia. The increased serum globulin found in cirrhosis, hyperglobulinemic purpura and hepatitis exhibits on paper electrophoresis diffuse and rounded peaks that are distinct from the discrete and homogeneous serum electrophoretic peaks found in the patients forming the basis of this report. Four male patients with discrete serum gamma globulin electrophoretic peaks have been observed for from two to three and one-half years without evidence of specific disease other than an inordinate susceptibility to infections. Although multiple myeloma may subsequently develop
HAMMACK WJ, BOLDING FE, FROMMEYER WB. THE DYSGAMMAGLOBULINEMIC SYNDROME12. Ann Intern Med. ;50:288–299. doi: 10.7326/0003-4819-50-2-288
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Published: Ann Intern Med. 1959;50(2):288-299.
Hematology/Oncology, Lupus Erythematosus, Multiple Myeloma, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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