ERNEST BEUTLER, M.D.
It has been recognized for many years that patients with hypochromic microcytic anemia usually respond to iron therapy.1 Conversely, it has usually been assumed that iron deficiency always causes a hypochromic microcytic anemia. Thus, it has been stated authoritatively that "hypochromic microcytic anemia . . . is the only type of anemia in which such treatment [iron] is clearly effective."2 More recently, it has been found that iron-sensitive anemias are also characterized by the absence of stainable iron in the sternal marrow,3 and often by reduction of the plasma iron concentration in association with an increase in the iron-binding capacity
BEUTLER E. THE RED CELL INDICES IN THE DIAGNOSIS OF IRON-DEFICIENCY ANEMIA(THE RED CELL INDICES IN THE DIAGNOSIS OF IRON-DEFICIENCY ANEMIA*). Ann Intern Med. 1959;50:313–322. doi: 10.7326/0003-4819-50-2-313
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Published: Ann Intern Med. 1959;50(2):313-322.
Hematology/Oncology, Red Cell Disorders.
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