THOMAS E. VAN METRE JR.; PAUL J. KADULL, M.D.
A high incidence of tularemia among nonvaccinated laboratory workers has been recognized.1-12 Almost every individual who consistently works with Pasteurella tularensis eventually incurs infection; those casually exposed may escape.3, 4
The clinical features of laboratory-acquired tularemia in nonvaccinated and previously uninfected individuals have been described in detailed reports of at least 19 cases.4-9 In general, these patients had a typhoidal illness, with moderate to severe symptoms and a relatively high incidence of chronic disability. No ulceroglandular cases have been reported. Several asymptomatic cases have been observed.
Tularemia has been reported in laboratory workers presumably immunized by prior infection. Francis2 cited
VAN METRE TE, KADULL PJ. LABORATORY-ACQUIRED TULAREMIA IN VACCINATED INDIVIDUALS: A REPORT OF 62 CASES12. Ann Intern Med. ;50:621–632. doi: 10.7326/0003-4819-50-3-621
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Published: Ann Intern Med. 1959;50(3):621-632.
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