MARVIN F. LEVITT, M.D.; MARVIN BELSKY, M.D.; DEMETRA POLIMEROS, B.S.
The development of serum hypertonicity in patients with primary cerebral disease is well known,1-15 although many of the reported cases do not fulfill the criteria which characterize this form of serum hypertonicity. The cerebral disease and its manifestations must precede the progressive elevation of the serum electrolyte concentrations. This sequence excludes the possibility that the hypertonicity and cerebral dysfunction stem from inadequate water intake with severe dehydration. Water intake should reach levels generally considered to be adequate, and the mean electrolyte concentration of the total intake should not exceed the tonicity of normal plasma. Finally, renal function should be reasonably
LEVITT MF, BELSKY M, POLIMEROS D. SERUM HYPERTONICITY SECONDARY TO CEREBRAL DISEASE1. Ann Intern Med. ;50:788–796. doi: 10.7326/0003-4819-50-3-788
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Published: Ann Intern Med. 1959;50(3):788-796.
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