JOSEPH B. KIRSNER, M.D., F.A.C.P.; WALTER L. PALMER, M.D., F.A.C.P.; JEAN A. SPENCER, M.D.; RICHARD O. BICKS, M.D.; CHARLES F. JOHNSON, M.D.
The ultimate role of corticotropin (ACTH), the adrenal steroids (cortisone, hydrocortisone) and related compounds (prednisone and prednisolone) in the management of ulcerative colitis remains to be established. Though the immediate beneficial effects of corticoid therapy now are generally recognized,1, 2, 3, 4 opinions vary.5, 6, 7 The unfavorable reports frequently concern small groups of patients given medication irregularly, or as a substitute for all other forms of treatment. The possible dangers of hormonal therapy also have been emphasized,8, 9, 10 though observers differ as to their incidence and importance.11, 12, 13, 14 The literature on corticoid therapy of gastrointestinal
KIRSNER JB, PALMER WL, SPENCER JA, BICKS RO, JOHNSON CF. CORTICOTROPIN (ACTH) AND THE ADRENAL STEROIDS IN THE MANAGEMENT OF ULCERATIVE COLITIS: OBSERVATIONS IN 240 PATIENTS12. Ann Intern Med. ;50:891–927. doi: 10.7326/0003-4819-50-4-891
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Published: Ann Intern Med. 1959;50(4):891-927.
Adrenal Disorders, Endocrine and Metabolism, Gastroenterology/Hepatology, Inflammatory Bowel Disease.
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