JOHN H. LAWRENCE, M.D., D.SC., F.A.C.P.; WILLIAM G. DONALD JR., M.D.
The possible causal relationship between hypernephroma and polycythemia was first strongly advanced by Forssell8 in 1946 when he described a patient with hypernephroma and polycythemia whose red cell count and hemoglobin returned to normal values following nephrectomy. This patient remained symptom-free and with normal blood values until 14 months later, when hematuria recurred. Studies at this time again revealed a significant elevation of the red cell count and hemoglobin. The patient died with uremia. Autopsy showed a metastasis or recurrence of the hypernephroma in the remaining kidney.9 Previous to this, Medvei in 1934 had reported a case of coexisting polycythemia,
LAWRENCE JH, DONALD WG. POLYCYTHEMIA AND HYDRONEPHROSIS OR RENAL TUMORS1. Ann Intern Med. ;50:959–969. doi: 10.7326/0003-4819-50-4-959
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Published: Ann Intern Med. 1959;50(4):959-969.
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