DANIEL O'CONNELL, M.D., F.F.R.
As far as is known, the first workers to indicate a hereditary influence in ankylosing spondylitis were the members of the Clinical Club in 1888. Both Sir Jonathan Hutchinson and Alexander Morrison stressed the significance of a family history of rheumatism or gout. Later the adjective "heredo-traumatique" was applied to von Bechterew's syndrome, and Marie and Astié in 18971 reported a sister and father who had had a similar disease. Geilinger in 19182 thought that heredity played a part in approximately 10% of cases, but interest in this aspect of the disease waned, apart from sporadic reports of involvement of
O'CONNELL D. HEREDITY IN ANKYLOSING SPONDYLITIS1. Ann Intern Med. ;50:1115–1121. doi: 10.7326/0003-4819-50-5-1115
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Published: Ann Intern Med. 1959;50(5):1115-1121.
Infectious Disease, Rheumatology.
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