E. STERLING NICHOL, M.D., F.A.C.P.; WILLIAM C. PHILLIPS, M.D.; GUS G. CASTEN, M.D.
The clinical pattern of coronary atherosclerosis is remarkably variable in different subjects, but observation over a period of years reveals that patients fall into groups delineated by the clinical progression of the disease, as depicted in the diagram below.
1. Patients with no previous signs of coronary disease who develop angina pectoris with or without detectable trigger factors such as smoking, dietary excess, gall-bladder disease, hiatal hernia or emotional stress. Some of this group go along well stabilized for years without obvious progression of their coronary disease, with intermittent pain modified by avoiding trigger mechanisms, restriction of activities, the use
NICHOL ES, PHILLIPS WC, CASTEN GG. VIRTUE OF PROMPT ANTICOAGULANT THERAPY IN IMPENDING MYOCARDIAL INFARCTION: EXPERIENCES WITH 318 PATIENTS DURING A 10-YEAR PERIOD1. Ann Intern Med. ;50:1158–1173. doi: 10.7326/0003-4819-50-5-1158
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Published: Ann Intern Med. 1959;50(5):1158-1173.
Acute Coronary Syndromes, Cardiology, Coronary Heart Disease, Emergency Medicine.
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