RONALD C. BISHOP, M.D., F.A.C.P.; HERBERT H. SPENCER, M.D.; FRANK H. BETHELL, M.D., F.A.C.P.
Although Seyderhelm1 in 1927, in a very brief clinical discussion, associated thrombocytopenic purpura with quinidine administration, Broch2 in 1941 was the first to give a detailed case report of this phenomenon, to speculate as to the mechanism of the thrombocytopenia, and to provide evidence that the thrombocytopenia was indeed due to an idiosyncrasy to quinidine. In the period from 1947 to 1955 numerous single case reports3-23 and a report of two cases by Bigelow and Desforges24 were published. Gold25 also mentioned two cases of thrombocytopenia due to quinidine in a discussion of quinidine therapy. Nudelman et al.5 expressed the opinion
BISHOP RC, SPENCER HH, BETHELL FH. QUINIDINE PURPURA: REPORT OF SIX CASES1. Ann Intern Med. ;50:1227–1240. doi: 10.7326/0003-4819-50-5-1227
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Published: Ann Intern Med. 1959;50(5):1227-1240.
Cardiology, Coagulopathies, Hematology/Oncology, Rhythm Disorders and Devices.
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