SEYMOUR M. FARBER, M.D.; ROGER H. L. WILSON, M.D.
Pharmacologic bronchodilators have been used perhaps as long as any known medicinal agent. The use of ephedrine (ma hwang) is shrouded in the mists of Chinese antiquity. The burning of stramonium leaves appears at least as early as the 17th Century in Western Europe. Thus, sympatheticomimetic substances and parasympathetic paralysants appear early in the treatment of "bronchospastic" disease. Today many different compounds are available to be used as bronchodilators. These fall largely into three groups:
1. Epinephrine and related compounds.
2. Derivatives of scopolamine or hyoscyamine.
3. Aminophylline and other related substances.
The route of administration, choice of drug, dosage
FARBER SM, WILSON RHL. THE RATIONAL APPROACH IN THE USE OF BRONCHODILATORS IN CHRONIC RESPIRATORY DISEASE1. Ann Intern Med. 1959;50:1241–1251. doi: 10.7326/0003-4819-50-5-1241
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Published: Ann Intern Med. 1959;50(5):1241-1251.
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