OTTO DEUTSCHBERGER; HERLEY FUJIY
Multiple myeloma was first described as an entity in 1889 by Kahler, who stated that the following features are characteristic of this disease:
1. Bone pain and abnormal fragility.
2. Anemia, weakness and loss of weight.
3. Presence of Bence Jones proteins in the urine.
The original description of multiple myeloma refers to diffusely infiltrating, intramedullary, multiple tumors which consist of myeloma cells. These cells could best be described as plasmoid cells, since they have the characteristics of young plasma cells. The tumors, frequently referred to as plasmacytomas, are found mainly in the flat bones.
Today, we know that multiple
DEUTSCHBERGER O, FUJIY H. ROENTGENOLOGIC AND CLINICAL ASPECTS OF MULTIPLE MYELOMA WITH REPORT OF AN UNUSUAL CASE1. Ann Intern Med. ;50:1309–1320. doi: 10.7326/0003-4819-50-5-1309
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Published: Ann Intern Med. 1959;50(5):1309-1320.
Hematology/Oncology, Multiple Myeloma.
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