JAMES M. MOSS, M.D., F.A.C.P.; DEWITT E. DELAWTER, M.D.; JOHN J. CANARY, M.D.
Satisfactory control of diabetes mellitus has been reported in more than half of the patients treated with tolbutamide.1, 2, 3 After an initial period of good response a few patients develop persistent hyperglycemia unresponsive to an increased dose. This secondary failure to respond has been reported in 0.3%4 to 14%5 of all patients. The incidence may be higher when more patients have been followed for a longer period of time. The records of 200 tolbutamide-treated patients have been reviewed in an effort to evaluate this and other problems.
The patients in the early part of this series
MOSS JM, DELAWTER DE, CANARY JJ. THE RESULTS OF THE TREATMENT WITH TOLBUTAMIDE OF 200 DIABETIC PATIENTS: A DISCUSSION OF SECONDARY FAILURE12. Ann Intern Med. ;50:1407–1417. doi: 10.7326/0003-4819-50-6-1407
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Published: Ann Intern Med. 1959;50(6):1407-1417.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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