HERMAN KABAT, M.D., Ph.D.
In an earlier paper1 it was reported that patients with cerebellar ataxia and intention tremor show deficiency of voluntary isometric (holding) contraction of the skeletal muscles, whereas voluntary isotonic (active motion) contraction is relatively unaffected. Testing against manual resistance reveals greater power and endurance in isotonic contraction than in isometric contraction of the same muscle or muscle group. This discrepancy between isometric and isotonic function in voluntary movement is greater the more severe the cerebellar asynergia. In unilateral cerebellar involvement, the predominance of isotonic over isometric contraction is found only on the side showing cerebellar signs. While all muscle groups
KABAT H. DRUG THERAPY OF CEREBELLAR ATAXIA AND DISORDERS OF THE BASAL GANGLIA, BASED ON CEREBELLAR-STRIATAL ANTAGONISM1. Ann Intern Med. ;50:1438–1448. doi: 10.7326/0003-4819-50-6-1438
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Published: Ann Intern Med. 1959;50(6):1438-1448.
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