EVELYN V. COONRAD; R. W. RUNDLES, F.A.C.P.
Ovarian carcinoma is the third most common malignancy arising from the female genital tract, and the one least amenable to successful treatment.1, 2 The tumor is notoriously "silent." Its discovery at an early stage is difficult, even in women who have frequent, routine pelvic examinations. Papanicolaou cytologic studies ordinarily give no clue as to its presence, and symptoms are unusual until invasion of the retroperitoneal pelvic tissues, bladder or bowel wall or intraperitoneal spread has occurred. At operation, viable tumor cells have been found in peritoneal washings in the great majority of patients, including many of those without visible metastases.3,
COONRAD EV, RUNDLES RW. MUSTARD CHEMOTHERAPY IN OVARIAN CARCINOMA11. Ann Intern Med. 1959;50:1449–1461. doi: 10.7326/0003-4819-50-6-1449
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Published: Ann Intern Med. 1959;50(6):1449-1461.
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