J. C. S. PATERSON; C. C. SPRAGUE
The periodic crises which punctuate the natural course of sickle cell anemia were separated by Singer and his colleagues17 in 1950 into the following categories: (a) the "aplastic" crisis, (b) the "hyperhemolytic" crisis, and (c) "the aplastic-hyperhemolytic" crisis, in which there is both an abeyance of the delivery of cells from the marrow and an increase in the rate of hemolysis of the circulating red cells. This hematologic classification has been generally accepted, but with more emphasis put upon the "thrombotic," "infarctive" or "symptomatic" crisis, an episode of fever and pain, without any significant change in the hemoglobin level.9, 19,
PATERSON JCS, SPRAGUE CC. OBSERVATION ON THE GENESIS OF CRISES IN SICKLE CELL ANEMIA12. Ann Intern Med. ;50:1502–1507. doi: 10.7326/0003-4819-50-6-1502
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Published: Ann Intern Med. 1959;50(6):1502-1507.
Hematology/Oncology, Red Cell Disorders.
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