LEWIS M. HURXTHAL, M.D., F.A.C.P.; JOHN B. O'SULLIVAN, M.D.
It is now accepted that the immediate cause of Cushing's syndrome is adrenocortical hyperfunction, regardless of the possible etiologic part played by the pituitary gland or the hypothalamus. The average duration of this syndrome from onset to death was estimated by Cushing1 to be slightly over five years. The major causes of death are infection, complications of cardiovascular disease, and neoplastic disease.2 The duration of the disease and its severity are considered to be important factors in treatment and prognosis.3 With a condition which is so potentially fatal, and in which the ravages of the disease are in part proportional
HURXTHAL LM, O'SULLIVAN JB. CUSHING'S SYNDROME: CLINICAL DIFFERENTIAL DIAGNOSIS AND COMPLICATIONS1. Ann Intern Med. ;51:1–16. doi: 10.7326/0003-4819-51-1-1
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Published: Ann Intern Med. 1959;51(1):1-16.
Adrenal Disorders, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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