J. SALVAGGIO, M.D.; F. GONZALEZ, M.D.
The ever-increasing problem of bacterial resistance to antibiotics has caused a "shift of the pendulum" back to the usage of sulfonamides in recent years. This fact has again brought into the spotlight the clinical toxicity of these chemotherapeutic agents. With the development of newer and more soluble compounds, renal toxicity has virtually ceased to exist, and there has been a marked decline of other types of reactions to these drugs. In his evaluation of the newer sulfonamides, Yow1 has listed their injurious effects as follows: fever, 1.5%; dermatitis, 1.5%; gastrointestinal toxicity, 1.3%; blood dyscrasias, 0.18%; hepatitis, 0.1%; renal toxicity, anaphylaxis,
SALVAGGIO J, GONZALEZ F. SEVERE TOXIC REACTIONS ASSOCIATED WITH SULFAMETHOXYPYRIDAZINE (KYNEX)1. Ann Intern Med. ;51:60–67. doi: 10.7326/0003-4819-51-1-60
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Published: Ann Intern Med. 1959;51(1):60-67.
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