JULIUS POMERANZE, M.D.
A chronic disease process always exists in a preclinical state, in which its symptomatology is absent or vague, and its biochemical and metabolic changes are minimal and nonspecific. At such time, diagnostic reliance cannot be placed upon those obvious biochemical changes or gross clinical findings which are clearly evident only in the overt phase of the disease. We must therefore distinguish between the presence of a disease process and the recognition of its obvious diagnostic features. Our concept of the natural history of chronic diseases must be broadened and our diagnostic acumen sharpened. Early recognition and treatment will most favorably
POMERANZE J. SUBTHRESHOLD DIABETES1. Ann Intern Med. ;51:219–226. doi: 10.7326/0003-4819-51-2-219
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Published: Ann Intern Med. 1959;51(2):219-226.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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