I. N. MARKS; CHARLES R. SHUMAN, F.A.C.P.; HARRY SHAY, F.A.C.P.
Earlier investigators have noted a high incidence of achlorhydria among diabetic patients. Bowen and Aaron1 found achlorhydria in 29% of 61 diabetic subjects, and Marble2 reported an incidence of 32.8% in a collected series of 399 such patients. Various modifications of the Ewald test were employed in these studies, and the results in many series were biased by the inclusion of diabetic patients known to have gastrointestinal disorders. The status of gastric secretion in diabetes mellitus does not appear to have been studied with more refined methods.
The augmented histamine test,3 based on maximal histamine stimulation, is perhaps the most
MARKS IN, SHUMAN CR, SHAY H. GASTRIC ACID SECRETION IN DIABETES MELLITUS1. Ann Intern Med. ;51:227–237. doi: 10.7326/0003-4819-51-2-227
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Published: Ann Intern Med. 1959;51(2):227-237.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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