ALAN S. COHEN, M.D.; NORMAN S. STEARNS, M.D.; HOWARD LEVITIN, M.D.; DAVID HURWITZ, M.D.
Rauwolfia serpentina has been reported to have a hypoglycemic effect on both normal and diabetic patients. Neugebauer and Lang1 gave Rauwolfia to 14 normal, three hypertensive and two diabetic patients. In the normal subjects the blood sugar fell an average of 13%, in the others, 11%. These investigators also reported that alloxan diabetic rats could be kept alive by administering Rauwolfia, whereas all untreated controls died in coma within two days. In contrast, Kuschke and Frantz2 described increased blood sugar levels in fasting rabbits after subcutaneous injection of reserpine at various dose levels ranging from 0.1 to 1.0 mg./kg.
COHEN AS, STEARNS NS, LEVITIN H, HURWITZ D. STUDIES ON RAUWOLFIA ALKALOIDS IN DIABETIC HYPERTENSIVE PATIENTS1. Ann Intern Med. 1959;51:238–247. doi: 10.7326/0003-4819-51-2-238
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Published: Ann Intern Med. 1959;51(2):238-247.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Hypertension.
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