ROSE RUTH ELLISON; RICHARD T. SILVER; RALPH L. ENGLE JR.
The results of comparing two consecutive series of adults with acute leukemia treated either with 6-mercaptopurine (6MP) or 6-chloropurine (6CP)1 suggested that both drugs behave similarly in many respects (table 1). That the action of these drugs would be similar in the human was suggested by their effect on transplanted Sarcoma 180 in mice, and by the resistance to 6CP of a 6MP-resistant strain of Sarcoma 180,2 even though 6CP is without significant effect in most strains of mouse leukemia.3 Nevertheless, a slightly increased frequency of remission and longer median survival time were observed in the group of adults
ELLISON RR, SILVER RT, ENGLE RL. COMPARATIVE STUDY OF 6-CHLOROPURINE AND 6-MERCAPTOPURINE IN ACUTE LEUKEMIA IN ADULTS1. Ann Intern Med. ;51:322–338. doi: 10.7326/0003-4819-51-2-322
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Published: Ann Intern Med. 1959;51(2):322-338.
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