SAMUEL K. ELSTER, M.D.; ELMER PADER, M.D.
In a previous publication1 the clinical and laboratory manifestations of acute rheumatic fever in 30 adult patients were studied. Treatment of these patients consisted of adrenocortical hormones or corticotropin, hereinafter referred to simply as hormones, salicylates, or a combination of these drugs. Very frequently, as drug therapy was diminished or discontinued, the reappearance of laboratory and/or clinical manifestations suggestive of rheumatic activity was noted. This "rebound phenomenon" had been noted previously by other authors, and much controversy has arisen concerning its significance. At times the "rebound" was manifested by the recrudescence of laboratory abnormalities only, such as elevation of
ELSTER SK, PADER E. STUDIES ON ACUTE RHEUMATIC FEVER IN THE ADULT. II. THE REBOUND PHENOMENON1. Ann Intern Med. ;51:339–358. doi: 10.7326/0003-4819-51-2-339
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Published: Ann Intern Med. 1959;51(2):339-358.
Infectious Disease, Rheumatology, Streptococcal Infections.
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