JOHN E. ULTMANN; WINTHROP FISH; ELLIOTT OSSERMAN; ALFRED GELLHORN, F.A.C.P.
Although many patients with agammaglobulinemia have been reported since 1952, there are few reports and surveys of serum gamma globulin depressions in association with chronic lymphocytic leukemia (CLL) and lymphocytic lymphosarcoma (LyLysa). The clinical implications of this complication are rarely mentioned. Jim and Reinhard reported one patient with agammaglobulinemia and chronic lymphocytic leukemia in 1956,1 and then reviewed 49 additional patients a year later.2 He noted that in his 50 unselected patients with chronic lymphocytic leukemia there was significant hypogammaglobulinemia (HGG) in about a third. Wall et al.3 performed filter paper electrophoretic analyses of the sera of 495 patients with
ULTMANN JE, FISH W, OSSERMAN E, GELLHORN A. THE CLINICAL IMPLICATIONS OF HYPOGAMMAGLOBULINEMIA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AND LYMPHOCYTIC LYMPHOSARCOMA12. Ann Intern Med. ;51:501–516. doi: 10.7326/0003-4819-51-3-501
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Published: Ann Intern Med. 1959;51(3):501-516.
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