MAURICE M. BLACK, M.D.; FRANCIS D. SPEER, M.D.; MARTIN L. STONE, M.D.
A principal limitation in the use of currently available cancer chemotherapy is bone marrow toxicity. The repeated use of drugs such as nitrogen mustard leads to progressive leukopenia, thrombocytopenia, anemia and, finally, marrow aplasia. This sequence of events is all too familiar to the clinician, who is often forced to choose between standing by helplessly and watching the cancer kill the patient, or repeating the use of drugs which may lead to a hemorrhagic diathesis and death.
Various attempts have been made to minimize the exposure of the host tissues to nitrogen mustard by such manipulations as intra-arterial injections in
BLACK MM, SPEER FD, STONE ML. PROTECTIVE ACTION OF AUTOLOGOUS MARROW AGAINST NITROGEN MUSTARD TOXICITY12. Ann Intern Med. ;51:517–525. doi: 10.7326/0003-4819-51-3-517
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Published: Ann Intern Med. 1959;51(3):517-525.
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