JACK D. HACKNEY, M.D.; MILTON G. CRANE, M.D.; CLARENCE C. COLLIER, M.D.; STANLEY ROKAW, M.D.; DONALD E. GRIGGS, M.D., F.A.C.P.
The syndrome of extreme obesity, hypoventilation, polycythemia and heart failure has been recognized with increasing frequency since 1955.1-18 The most characteristic cardiorespiratory dysfunction in these patients is hypoventilation, evidenced by an elevated arterial PCO2. The physiologic alteration encountered in patients with the obesity-hypoventilation syndrome implicates excessive breathing work as a cause for the hypoventilation and attendant features. Our studies of 17 patients with this syndrome and our experimental studies on controls support this concept.
Hypoventilation frequently accompanies other clinical situations, i.e., emphysema, kyphoscoliosis and ventilatory restriction. It has been postulated in these entities that the hypoventilation observed is "an adaptation
HACKNEY JD, CRANE MG, COLLIER CC, ROKAW S, GRIGGS DE. SYNDROME OF EXTREME OBESITY AND HYPOVENTILATION: STUDIES OF ETIOLOGY(SYNDROME OF EXTREME OBESITY AND HYPOVENTILATION: STUDIES OF ETIOLOGY*). Ann Intern Med. 1959;51:541–552. doi: 10.7326/0003-4819-51-3-541
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Published: Ann Intern Med. 1959;51(3):541-552.
Obesity, Pulmonary/Critical Care.
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