MILTON S. SACKS, M.D., F.A.C.P.; ALEXANDER S. WIENER, M.D., F.A.C.P.; ELSA F. JAHN, B.S.; CARROLL L. SPURLING, M.D.; LESTER J. UNGER, M.D.
Immediately following the announcement of the discovery of the Rh factor by Landsteiner and Wiener1 two decades ago came the demonstration of the role of Rh sensitization in the causation of hemolytic transfusion reactions,2 and in the pathogenesis of erythroblastosis fetalis.3 As a result, routine Rh testing has become an essential part of the management of expectant mothers and of the selection of donors for blood transfusion. Study of serums from isosensitized patients has demonstrated that while the bulk of clinical problems are caused by sensitization to the originally described rhesus factor, now designated Rho2, many other blood factors belonging
SACKS MS, WIENER AS, JAHN EF, SPURLING CL, UNGER LJ. ISOSENSITIZATION TO A NEW BLOOD FACTOR, RhD, WITH SPECIAL REFERENCE TO ITS CLINICAL IMPORTANCE1. Ann Intern Med. 1959;51:740–747. doi: 10.7326/0003-4819-51-4-740
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Published: Ann Intern Med. 1959;51(4):740-747.
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