F. RAMOS-MORALES, M.D.; R. S. DÍAZ-RIVERA, M.D., F.A.C.P.; A. A. CINTRÓN-RIVERA, M.D.; JOSÉ A. RULLÁN, M.D.; A. S. BENENSON; JOSEFINA ACOSTA-MATIENZO, M.S.
Although the pathogenesis of jaundice in leptospirosis (Weil's disease) has been the subject of a great deal of speculation, it has been most frequently attributed to hemolysis and intrahepatic biliary obstruction. Many textbooks either tacitly avoid the subject or conclude, reflecting the general opinion, that the exact pathogenesis of jaundice in this disease is unknown.1 The scarce material in the American medical literature does not reflect the complete clinical picture of the disease, since most of the patients studied presented intense jaundice and were severely ill.2-4 Medical reports from Europe, frequently based on a large number of cases, lack laboratory
RAMOS-MORALES F, DÍAZ-RIVERA RS, CINTRÓN-RIVERA AA, RULLÁN JA, BENENSON AS, ACOSTA-MATIENZO J. THE PATHOGENESIS OF LEPTOSPIRAL JAUNDICE1. Ann Intern Med. 1959;51:861–878. doi: 10.7326/0003-4819-51-5-861
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Published: Ann Intern Med. 1959;51(5):861-878.
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