JAMES W. LINMAN, M.D.; FRANK H. BETHELL, M.D., F.A.C.P.; MARTHA J. LONG, M.S.
It has long been evident that erythropoiesis is governed by equilibrated forces which maintain the normal erythroid steady state and determine erythropoietic responses to stimuli arising from physiologic and pathologic changes. Until recently, however, little was known concerning the manner by which erythrocytic equilibrium was maintained or restored. During the last few years, studies in many laboratories have established the existence of a humoral erythropoietic regulatory mechanism,1, 2 and evidence is now available which suggests that the formation of other hemic elements may be subject to similar controlling factors.
Our previous studies3-5 indicate that two humoral factors exert control over
LINMAN JW, BETHELL FH, LONG MJ. FACTORS CONTROLLING HEMOPOIESIS: EXPERIMENTAL OBSERVATIONS ON THEIR ROLE IN POLYCYTHEMIA VERA1. Ann Intern Med. ;51:1003–1018. doi: 10.7326/0003-4819-51-5-1003
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Published: Ann Intern Med. 1959;51(5):1003-1018.
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