ROBERT H. WILLIAMS, M.D., F.A.C.P.; RICHARD H. POLLEN, M.D.; DONALD C. TANNER, M.D.; ROBERT H. BARNES, M.D.
There is some evidence suggesting that the majority of patients with diabetes have subnormal concentrations of insulin in the plasma, but a hypernormal quantity of insulin has been demonstrated in certain instances. Insulin administration has proved to be of tremendous value, especially in those types of diabetes which seem to be associated with subnormal amounts of this hormone, for example, juvenile diabetes. Nevertheless, almost all of the juvenile diabetics develop one or more of the chronic complications of diabetes (retinopathy, intercapillary glomerulosclerosis, etc.) within an interval of 20 years, regardless of ardent efforts by the patients and their physicians to
WILLIAMS RH, POLLEN RH, TANNER DC, BARNES RH. ORAL ANTIDIABETIC THERAPY12. Ann Intern Med. ;51:1121–1133. doi: 10.7326/0003-4819-51-6-1121
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Published: Ann Intern Med. 1959;51(6):1121-1133.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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