MICHAEL A. RUBINSTEIN, M.D., F.A.C.P.; BENJAMIN M. KAGAN, M.D., F.A.C.P.; MARGARET H. MACGILLVIRAY, M.D.; REUBEN MERLISS, M.D., F.A.C.P.; HARRY SACKS, M.D.
Ever since its original description by Moschcowitz in 19251 as "an acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries" associated with a bleeding tendency, thrombotic thrombocytopenic purpura (TTP) has been reported with increasing frequency, especially in the last decade.2, 3, 4 With 78 cases reported in the available literature, and more known not to have been recorded, the disease is no longer considered to be unusually rare.
The anemia has been shown to be hemolytic, and the hemorrhagic tendency to be due to thrombocytopenia. However, the nature of the characteristic vascular thrombi has not been
RUBINSTEIN MA, KAGAN BM, MACGILLVIRAY MH, MERLISS R, SACKS H. UNUSUAL REMISSION IN A CASE OF THROMBOTIC THROMBOCYTOPENIC PURPURA SYNDROME FOLLOWING FRESH BLOOD EXCHANGE TRANSFUSIONS1. Ann Intern Med. ;51:1409–1419. doi: 10.7326/0003-4819-51-6-1409
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Published: Ann Intern Med. 1959;51(6):1409-1419.
Coagulopathies, Hematology/Oncology, Platelet Disorders.
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