H. J. ROBERTS, M.D.
This paper reports a patient with a bronchogenic carcinoma who developed profound hyponatremia and hypochloremia in association with considerable loss of both sodium and chloride in the urine. Clinically he was found to have normal renal and adrenal function and at autopsy the kidneys and the adrenals showed no significant pathologic change.
Two earlier instances of this particular syndrome were included in the report by Schwartz et al. in 1957.1 It was the opinion of these investigators that this unusual electrolyte derangement could best be explained by a sustained and inappropriate secretion of antidiuretic hormone, and that this disorder was
ROBERTS HJ. THE SYNDROME OF HYPONATREMIA AND RENAL SODIUM LOSS PROBABLY RESULTING FROM INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE1. Ann Intern Med. ;51:1420–1426. doi: 10.7326/0003-4819-51-6-1420
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Published: Ann Intern Med. 1959;51(6):1420-1426.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology, Neurology.
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