HOWARD J. WETSTONE, M.D.; RUDOLPH V. LAMOTTA, M.D.; ALDO BELLUCCI, M.D.; ROBERT TENNANT, M.D.; BENJAMIN V. WHITE, M.D., F.A.C.P.
Although several reports have described a depression of serum cholinesterase activity in patients with neoplastic disease, a clear correlation has not been established between the quantitative level of enzyme activity, the site of origin and degree of spread of the tumor, the function of the liver and the clinical status of the individual patient. In the absence of a satisfactory explanation of this phenomenon, further investigations of the metabolism of the enzyme in the tumor state seemed warranted.
Serum cholinesterase (pseudocholinesterase) is manufactured by the liver1-5 and found in serum, plasma, pancreas, brain and certain other body tissues.6-9 It is
WETSTONE HJ, LAMOTTA RV, BELLUCCI A, TENNANT R, WHITE BV. STUDIES OF CHOLINESTERASE ACTIVITY. V. SERUM CHOLINESTERASE IN PATIENTS WITH CARCINOMA(STUDIES OF CHOLINESTERASE ACTIVITY. V. SERUM CHOLINESTERASE IN PATIENTS WITH CARCINOMA*†)(STUDIES OF CHOLINESTERASE ACTIVITY. V. SERUM CHOLINESTERASE IN PATIENTS WITH CARCINOMA*†). Ann Intern Med. 1960;52:102–125. doi: 10.7326/0003-4819-52-1-102
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Published: Ann Intern Med. 1960;52(1):102-125.
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