LOWELL A. RANTZ, M.D., F.A.C.P.
The most interesting developments in the field of antimicrobial therapy have centered about the introduction of a number of new agents. Some of these are modifications of, or are closely related to, drugs already in use, whereas others are completely new.
Sulfonamides: Two sulfonamide drugs, sulfamethoxypyridazine (Kynex)1 and sulfadimethoxine (Madribon),2, 3 have recently received wide clinical trial. Both have similar properties in that they are absorbed rapidly and well from the gastrointestinal tract and excreted slowly by the kidney. Treatment is thus possible with a single daily dose of 0.5 to 1.0 gm., and renal complications due to a high
RANTZ LA. RECENT DEVELOPMENTS IN ANTIBIOTIC THERAPY1. Ann Intern Med. ;52:362–367. doi: 10.7326/0003-4819-52-2-362
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Published: Ann Intern Med. 1960;52(2):362-367.
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