CLAUDE-STARR WRIGHT, M.D., F.A.C.P.; EDWARD GARDNER JR., Ph.D.
We have been impressed by the frequent coincidence of acute hemolytic crises in chronic hemolytic syndromes and the onset of acute infectious states such as the common cold. Herrick,1 in the first reported case of sickle cell anemia in 1910, observed: "Two days prior to examination he had 'taken cold,' his cough had grown worse and he had a slight chill, followed by fever." This association has been noted by other observers.2, 3
To validate this clinical impression, we reviewed 23 consecutive admissions to our hospital of patients with sickle cell anemia in acute hemolytic crisis (table 1). All had
WRIGHT C, GARDNER E. A STUDY OF THE ROLE OF ACUTE INFECTIONS IN PRECIPITATING CRISES IN CHRONIC HEMOLYTIC STATES12. Ann Intern Med. ;52:530–537. doi: 10.7326/0003-4819-52-3-530
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Published: Ann Intern Med. 1960;52(3):530-537.
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