A. IANNACCONE, M.D.; J. L. GABRILOVE, M.D., F.A.C.P.; S. A. BRAHMS, M.D.; L. J. SOFFER, M.D., F.A.C.P.
Osteoporosis is a striking and serious feature of Cushing's syndrome. This manifestation of the disease is evidenced by the demineralization seen on the roentgenogram, and by the frequent occurrence of pathologic fractures. Indeed, the collapse of the weakened vertebrae causes shortness of stature and contributes to the characteristic truncal obesity of the patient with this disease. It has been known for many years that, following cure of the disease, further collapse of the vertebrae ceases and pathologic fractures no longer appear. However, there are scant data as to what occurs in the bony skeleton following successful treatment of the disease.
IANNACCONE A, GABRILOVE JL, BRAHMS SA, SOFFER LJ. OSTEOPOROSIS IN CUSHING'S SYNDROME1. Ann Intern Med. ;52:570–586. doi: 10.7326/0003-4819-52-3-570
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Published: Ann Intern Med. 1960;52(3):570-586.
Adrenal Disorders, Endocrine and Metabolism, Metabolic Bone Disorders.
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