LEO L. MORGENSTERN, M.B., B.S. (Melbourne)
Chlorpropamide is a new oral sulfonylurea. Like tolbutamide, the other sulfonylurea presently available in the United States, chlorpropamide has no antibacterial activity. It is rapidly absorbed from the gastrointestinal tract of man; within one hour after a single oral dose it attains readily detectable blood levels,1 which reach a peak within two to four hours.2, 3
Chlorpropamide blood levels diminish gradually, the drug being excreted slowly in the urine as the active hypoglycemic material. Within 96 hours, in man, 65 to 90% of a single oral dose of chlorpropamide is excreted in the urine.1
The half-time of its disappearance from
MORGENSTERN LL. SOME OBSERVATIONS ON THE USE OF CHLORPROPAMIDE IN PRIMARY TOLBUTAMIDE-FAILURE DIABETICS(SOME OBSERVATIONS ON THE USE OF CHLORPROPAMIDE IN PRIMARY TOLBUTAMIDE-FAILURE DIABETICS*†)(SOME OBSERVATIONS ON THE USE OF CHLORPROPAMIDE IN PRIMARY TOLBUTAMIDE-FAILURE DIABETICS*†). Ann Intern Med. 1960;52:761–772. doi: 10.7326/0003-4819-52-4-761
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Published: Ann Intern Med. 1960;52(4):761-772.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Hospital Medicine.
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