A. E. THOMSON, M.D., F.R.C.P.(C); E. G. BROWNELL, M.D., F.A.C.P., F.R.C.P.(C); G. R. CUMMING, M.D., F.R.C.P.(C)
One of the earliest and most widely used screening tests for adrenal cortical insufficiency was that proposed by Robinson, Power and Kepler, which depended upon the inability of patients with Addison's disease to show a normal water diuresis. This procedure was subsequently found to exclude erroneously some cases of Addison's disease.1, 2 Moreover, the required 12-hour period of fluid restriction and the relatively large water load of 20 ml./Kg. were capable of inducing crises in the adrenal-deficient subject. In many centers a more direct method of diagnosis, by measurement of the changes in 17-hydroxycorticoid excretion before and after ACTH, superseded
THOMSON AE, BROWNELL EG, CUMMING GR. WATER DIURESIS IN ADRENAL CORTICAL INSUFFICIENCY1. Ann Intern Med. ;52:949–959. doi: 10.7326/0003-4819-52-5-949
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Published: Ann Intern Med. 1960;52(5):949-959.
Adrenal Disorders, Endocrine and Metabolism.
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