W. M. MIKKELSEN, M.D.; I. F. DUFF, M.D., F.A.C.P.; L. GOODSON, M.D.; W. H. COULTER, B.S.; C. HERTZ, B.S.
In 1931 Nicholls and Stainsby1 reported that the serum of many patients with rheumatoid arthritis was capable of agglutinating certain strains of streptococci. Subsequently it has been demonstrated2 that this is not a specific reaction with the streptococcus, but that, under suitable conditions, agglutination of a variety of indicator particles can be produced by rheumatoid sera. The so-called "rheumatoid factor" responsible for this agglutination phenomenon has been extensively studied in an attempt to gain better understanding of the basic pathogenesis of the disease. It has been shown to behave electrophoretically as a gamma globulin,3, 4 to have the solubility characteristics
MIKKELSEN WM, DUFF IF, GOODSON L, COULTER WH, HERTZ C. A COMPARATIVE STUDY OF SOME RECENT SEROLOGIC TESTS FOR RHEUMATOID ARTHRITIS12. Ann Intern Med. ;52:1051–1058. doi: 10.7326/0003-4819-52-5-1051
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Published: Ann Intern Med. 1960;52(5):1051-1058.
Rheumatoid Arthritis, Rheumatology.
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