WILLIAM FRAIMOW; RICHARD T. CATHCART; RICHARD C. TAYLOR
The recently described disease, pulmonary alveolar proteinosis,1 has aroused much clinical and pathologic interest. This disease bears a significant mortality (30%) in the reported cases. Death is the result of progressive pulmonary insufficiency, hastened at times by complicating secondary infection. A patient followed by this laboratory and previously reported demonstrated the presence of alveolar-capillary block.2 Since then, the almost identical physiologic findings in additional patients would seem to establish this picture conclusively as the expected physiologic abnormality in this condition. These abnormalities are related to specific histologic aberrations typically found in alveolar proteinosis. Its features are quite unlike the changes
FRAIMOW W, CATHCART RT, TAYLOR RC. PHYSIOLOGIC AND CLINICAL ASPECTS OF PULMONARY ALVEOLAR PROTEINOSIS12. Ann Intern Med. ;52:1177–1194. doi: 10.7326/0003-4819-52-6-1177
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Published: Ann Intern Med. 1960;52(6):1177-1194.
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