N. I. GALLAGHER, M.D.; J. M. MCCARTHY, M.D.; R. D. LANGE, M.D., F.A.C.P.
During the last decade the clinical and experimental observations of numerous investigators have established the concept that erythropoiesis is regulated in part by humoral factors. Recent extensive reports1-6 indicate the present interest in this subject; nonetheless, select areas are unexplored, while others remain controversial. The part played by disturbances of the humoral regulatory mechanism in the pathogenesis of anemia is essentially unknown and the existence of single or multiple factors is debated.7-10 Likewise, the site of production of the regulatory factor(s) is not clear. Jacobson's11-14 experiments point to the kidney as the source or activator of the humoral factor(s). Other
GALLAGHER NI, MCCARTHY JM, LANGE RD. OBSERVATIONS ON ERYTHROPOIETIC-STIMULATING FACTOR (ESF) IN THE PLASMA OF UREMIC AND NONUREMIC ANEMIC PATIENTS12. Ann Intern Med. ;52:1201–1212. doi: 10.7326/0003-4819-52-6-1201
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Published: Ann Intern Med. 1960;52(6):1201-1212.
Hematology/Oncology, Hospital Medicine, Nephrology, Red Cell Disorders.
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